Nijhout2006_Hepatic_Folate_Metab Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_cytosolic_tetrahydrofolate",
        "units": "native SBML value",
        "default": 13.333333333333334,
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.initial_cytosolic_tetrahydrofolate",
        "description": "Initial condition for cytosolic tetrahydrofolate. Maps to bundled SBML symbol `c_thf`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
      },
      {
        "name": "initial_mitochondrial_tetrahydrofolate",
        "units": "native SBML value",
        "default": 40,
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.initial_mitochondrial_tetrahydrofolate",
        "description": "Initial condition for mitochondrial tetrahydrofolate. Maps to bundled SBML symbol `m_thf`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from Tellurium setup-time value because no explicit SBML initial value was available."
      },
      {
        "name": "initial_folate_metabolism_state_3",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.initial_folate_metabolism_state_3",
        "description": "Initial condition for folate metabolism state 3. Maps to bundled SBML symbol `c_5mf`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_folate_metabolism_state_4",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.initial_folate_metabolism_state_4",
        "description": "Initial condition for folate metabolism state 4. Maps to bundled SBML symbol `c_2cf`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_folate_metabolism_state_5",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.initial_folate_metabolism_state_5",
        "description": "Initial condition for folate metabolism state 5. Maps to bundled SBML symbol `c_1cf`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "cytosolic_tetrahydrofolate",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.cytosolic_tetrahydrofolate"
      },
      {
        "name": "mitochondrial_tetrahydrofolate",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.mitochondrial_tetrahydrofolate"
      },
      {
        "name": "folate_metabolism_state_3",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.folate_metabolism_state_3"
      },
      {
        "name": "folate_metabolism_state_4",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.folate_metabolism_state_4"
      },
      {
        "name": "folate_metabolism_state_5",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.folate_metabolism_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.observable_labels"
      }
    ]
  },
  "title": "Nijhout2006_Hepatic_Folate_Metab Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model",
      "parameters": {
        "model_path": "data/MODEL1007200000.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model_observable_values"
      ],
      "from": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model_run_summary"
      ],
      "from": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model_observable_labels"
      ],
      "from": "metabolism_sbml_nijhout2006_hepatic_folate_metab_model1007200000_model.observable_labels"
    }
  ],
  "package": "nijhout2006-hepatic-folate-metab",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This is the model described in the article: In silico experimentation with a model of hepatic mitochondrial folate metabolism. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}