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This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison. It can be used to explore systemsbiology ratushny2012 spf BioModels0000000418 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_p",
"label": "Initial Model State P",
"maps_to": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.initial_model_state_p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `P`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.species_labels"
},
{
"name": "model_state_p",
"maps_to": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.model_state_p"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Ratushny2012 Spf Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model_state"
],
"from": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model_summary"
],
"from": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model_species_labels"
],
"from": "systemsbiology_sbml_ratushny2012_spf_biomd0000000418_model.species_labels"
}
],
"package": "ratushny2012-spf",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This model is from the article: Asymmetric positive feedback loops reliably control biological responses Alexander V Ratushny, Ramsey A Saleem, Katherine Sitko, Stephen A Ramsey & John D Aitchison. It can be used to explore systemsbiology ratushny2012 spf BioModels0000000418 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageratushny2012-spf
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother