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Restif2007 - Vaccination invasion This model is described in the article: Vaccination and the dynamics of immune evasion. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_immune_observable_1",
"label": "Initial Unresolved Immune Observable 1",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.initial_unresolved_immune_observable_1",
"description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `N`."
},
{
"name": "initial_unresolved_immune_observable_2",
"label": "Initial Unresolved Immune Observable 2",
"units": "native source value",
"default": 0.0588235,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.initial_unresolved_immune_observable_2",
"description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `S`."
},
{
"name": "initial_unresolved_immune_observable_3",
"label": "Initial Unresolved Immune Observable 3",
"units": "native source value",
"default": 0.00176967,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.initial_unresolved_immune_observable_3",
"description": "Initial Unresolved Immune Observable 3. Sets the initial value of bundled SBML species `I1`."
},
{
"name": "initial_unresolved_immune_observable_4",
"label": "Initial Unresolved Immune Observable 4",
"units": "native source value",
"default": 0.000001,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.initial_unresolved_immune_observable_4",
"description": "Initial Unresolved Immune Observable 4. Sets the initial value of bundled SBML species `I2`."
},
{
"name": "initial_unresolved_immune_observable_5",
"label": "Initial Unresolved Immune Observable 5",
"units": "native source value",
"default": 0.439407,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.initial_unresolved_immune_observable_5",
"description": "Initial Unresolved Immune Observable 5. Sets the initial value of bundled SBML species `R1`."
},
{
"name": "vaccine_immune_period_yr_parameter",
"label": "Vaccine Immune Period Yr Parameter",
"units": "time",
"default": 50,
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.vaccine_immune_period_yr_parameter",
"description": "Vaccine Immune Period Yr Parameter. Sets bundled SBML parameter `tImm_V`."
}
],
"outputs": [
{
"name": "unresolved_immune_observable_1",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.unresolved_immune_observable_1"
},
{
"name": "unresolved_immune_observable_2",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.unresolved_immune_observable_2"
},
{
"name": "unresolved_immune_observable_3",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.unresolved_immune_observable_3"
},
{
"name": "unresolved_immune_observable_4",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.unresolved_immune_observable_4"
},
{
"name": "unresolved_immune_observable_5",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.unresolved_immune_observable_5"
},
{
"name": "state",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.species_labels"
}
]
},
"title": "Restif2007 - Vaccination invasion Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model_state"
],
"from": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.state"
},
{
"to": [
"visualisation.immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model_summary"
],
"from": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model_species_labels"
],
"from": "immunology_sbml_restif2007_vaccination_invasion_biomd0000000294_model.species_labels"
}
],
"package": "restif2007-vaccination-invasion",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Restif2007 - Vaccination invasion This model is described in the article: Vaccination and the dynamics of immune evasion. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagerestif2007-vaccination-invasion
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother