Karlstaedt2019 G6p Accumulation Pgi Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "karlstaedt2019_g6p_accumulation_pgi_viz.run_summary"
      }
    ]
  },
  "title": "Karlstaedt2019 G6p Accumulation Pgi Lab",
  "models": [
    {
      "path": "models/scenario",
      "alias": "karlstaedt2019_g6p_accumulation_pgi_scenario",
      "parameters": {
        "schedule": {
          "cellular_energy_pool": {
            "unit": "dimensionless",
            "label": "cellular energy pool",
            "active": false,
            "baseline": 3.0417,
            "recovery": 3.0417,
            "challenge": 3.0417,
            "description": "Scenario-controlled cellular energy pool value."
          },
          "extracellular_glucose": {
            "unit": "dimensionless",
            "label": "extracellular glucose",
            "active": true,
            "baseline": 5.5,
            "recovery": 5.5,
            "challenge": 8.25,
            "description": "Scenario-controlled extracellular glucose value."
          }
        },
        "scenario_name": "Metabolic capacity challenge",
        "baseline_until": 150,
        "challenge_until": 450,
        "scenario_description": "Baseline is followed by a extracellular glucose challenge and recovery period."
      }
    },
    {
      "path": "./models/core",
      "alias": "karlstaedt2019_g6p_accumulation_pgi_core",
      "parameters": {
        "model_path": "data/MODEL1910170001.xml",
        "integration_step": 1
      }
    },
    {
      "path": "./models/viz",
      "alias": "karlstaedt2019_g6p_accumulation_pgi_viz",
      "parameters": {
        "lab_title": "Karlstaedt2019 G6p Accumulation Pgi",
        "lab_question": "Does phosphoglucose isomerase inhibition accumulate glucose-6-phosphate?",
        "integration_step": 1
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "karlstaedt2019_g6p_accumulation_pgi_core.extracellular_glucose"
      ],
      "from": "karlstaedt2019_g6p_accumulation_pgi_scenario.extracellular_glucose"
    },
    {
      "to": [
        "karlstaedt2019_g6p_accumulation_pgi_core.cellular_energy_pool"
      ],
      "from": "karlstaedt2019_g6p_accumulation_pgi_scenario.cellular_energy_pool"
    },
    {
      "to": [
        "karlstaedt2019_g6p_accumulation_pgi_viz.scenario_metadata"
      ],
      "from": "karlstaedt2019_g6p_accumulation_pgi_scenario.scenario_metadata"
    },
    {
      "to": [
        "karlstaedt2019_g6p_accumulation_pgi_viz.state"
      ],
      "from": "karlstaedt2019_g6p_accumulation_pgi_core.state"
    },
    {
      "to": [
        "karlstaedt2019_g6p_accumulation_pgi_viz.species_labels"
      ],
      "from": "karlstaedt2019_g6p_accumulation_pgi_core.species_labels"
    }
  ],
  "package": "karlstaedt2019-g6p-accumulation-pgi",
  "runtime": {
    "duration": 600,
    "initial_inputs": {
      "karlstaedt2019_g6p_accumulation_pgi_core": {
        "integration_step": 1,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Two-model lab for Karlstaedt2019 G6p Accumulation Pgi: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This model is described in the article: Glucose 6-phosphate accumulates via phosphoglucose isomerase inhibition in heart muscle. Karlstaedt, A and Khanna, R and Thangam, M and Taegtmeyer, H Circulatio.",
  "schema_version": "2.0"
}