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The model is based on MODEL1905220001 but has two compartments that have different composition of the biosynthetic enzymes NADA and NamPT. One compartment contains in addition NNMT, the other one does.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_sah",
"label": "Initial Model State Sah",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_model_state_sah",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SAH_NamPT_compartment`."
},
{
"name": "initial_model_state_pi",
"label": "Initial Model State Pi",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_model_state_pi",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Pi_NamPT_compartment`."
},
{
"name": "initial_model_state_pi_2",
"label": "Initial Model State Pi 2",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_model_state_pi_2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Pi_NADA_compartment`."
},
{
"name": "initial_prpp",
"label": "Initial Prpp",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_prpp",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PRPP_NamPT_compartment`."
},
{
"name": "initial_prpp_2",
"label": "Initial Prpp 2",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_prpp_2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PRPP_NADA_compartment`."
},
{
"name": "initial_nam_ex",
"label": "Initial Nam Ex",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.initial_nam_ex",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Nam_ex`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.species_labels"
},
{
"name": "sah",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.sah"
},
{
"name": "model_state_pi",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.model_state_pi"
},
{
"name": "model_state_pi_2",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.model_state_pi_2"
},
{
"name": "prpp",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.prpp"
},
{
"name": "prpp_2",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.prpp_2"
},
{
"name": "nam_ex",
"maps_to": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.nam_ex"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Heiland2019 Two Compartment Model Of Nad Biosynthesis And Consumption Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model_state"
],
"from": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model_summary"
],
"from": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model_species_labels"
],
"from": "systemsbiology_sbml_heiland2019_two_compartment_model_of_nad_biosynt_model1905220002_model.species_labels"
}
],
"package": "heiland2019-two-compartment-model-of-nad-biosynthesis-a-977f250b",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "The model is based on MODEL1905220001 but has two compartments that have different composition of the biosynthetic enzymes NADA and NamPT. One compartment contains in addition NNMT, the other one does.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageheiland2019-two-compartment-model-of-nad-biosynthesis-a-977f250b
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother