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This is a simple mathematical model describing the growth and removal of normal and leukemic haematopoietic stem cell populations and the role of these cellular processes in generating monoclonal leuk. It can be used to explore systemsbiology cucuianu2010 a hypothetical mathematical o dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_y_leukemic_cell",
"label": "Initial Y Leukemic Cell",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.initial_y_leukemic_cell",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `y_Leukemic_Cell`."
},
{
"name": "initial_x_normal_hematopoietic_stem_cell",
"label": "Initial X Normal Hematopoietic Stem Cell",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.initial_x_normal_hematopoietic_stem_cell",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `x_Normal_Hematopoietic_Stem_Cell`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.species_labels"
},
{
"name": "y_leukemic_cell",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.y_leukemic_cell"
},
{
"name": "x_normal_hematopoietic_stem_cell",
"maps_to": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.x_normal_hematopoietic_stem_cell"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Cucuianu2010 A Hypothetical Mathematical Model Of Acute Myeloid Leukaem Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model_state"
],
"from": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model_summary"
],
"from": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model_species_labels"
],
"from": "systemsbiology_sbml_cucuianu2010_a_hypothetical_mathematical_model_o_biomd0000000799_model.species_labels"
}
],
"package": "cucuianu2010-a-hypothetical-mathematical-model-of-acute-dedf2386",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is a simple mathematical model describing the growth and removal of normal and leukemic haematopoietic stem cell populations and the role of these cellular processes in generating monoclonal leuk. It can be used to explore systemsbiology cucuianu2010 a hypothetical mathematical o dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagecucuianu2010-a-hypothetical-mathematical-model-of-acute-dedf2386
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother