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Mathematical model of thrombin inhibition by ATIII, alpha-2-macroglobulin and miscellaneous serpins (a1-antitrypsin, a1-proteinase inhibitor, a1-antichymotrypsin, protease nexin-1, C1inhibitor and oth. It can be used to explore systemsbiology kremers2015 thrombin inhibitor kinetics model1808210001 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_a2_m",
"label": "Initial A2 M",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_a2_m",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `a2M`."
},
{
"name": "initial_t_a2_m",
"label": "Initial T A2 M",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_a2_m",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_a2M`."
},
{
"name": "initial_t_ms",
"label": "Initial T Ms",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_ms",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_MS`."
},
{
"name": "initial_t_at",
"label": "Initial T At",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_t_at",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T_AT`."
},
{
"name": "initial_model_state_at",
"label": "Initial Model State At",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_model_state_at",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `AT`."
},
{
"name": "initial_model_state_ms",
"label": "Initial Model State Ms",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.initial_model_state_ms",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MS`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.species_labels"
},
{
"name": "a2_m",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.a2_m"
},
{
"name": "t_a2_m",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_a2_m"
},
{
"name": "t_ms",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_ms"
},
{
"name": "t_at",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.t_at"
},
{
"name": "model_state_at",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.model_state_at"
},
{
"name": "model_state_ms",
"maps_to": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.model_state_ms"
}
]
},
"tags": [
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Kremers2015 Thrombin Inhibitor Kinetics Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model_state"
],
"from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model_summary"
],
"from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model_species_labels"
],
"from": "systemsbiology_sbml_kremers2015_thrombin_inhibitor_kinetics_model1808210001_model.species_labels"
}
],
"package": "kremers2015-thrombin-inhibitor-kinetics",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Mathematical model of thrombin inhibition by ATIII, alpha-2-macroglobulin and miscellaneous serpins (a1-antitrypsin, a1-proteinase inhibitor, a1-antichymotrypsin, protease nexin-1, C1inhibitor and oth. It can be used to explore systemsbiology kremers2015 thrombin inhibitor kinetics model1808210001 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagekremers2015-thrombin-inhibitor-kinetics
Created2026-05-17
Updated2026-06-13
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother