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This is the model described in the article: A biochemical model of matrix metalloproteinase 9 activation and inhibition. It can be used to explore systemsbiology vempati2007 mmp9 regulation model7888000034 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tr_pm9_t1_m3",
"label": "Initial Tr PM9 T1 M3",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_tr_pm9_t1_m3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Tr_pM9_T1_M3`."
},
{
"name": "initial_tr_pm9_t1",
"label": "Initial Tr PM9 T1",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_tr_pm9_t1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Tr_pM9_T1`."
},
{
"name": "initial_tr_pm9",
"label": "Initial Tr PM9",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_tr_pm9",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Tr_pM9`."
},
{
"name": "initial_model_state_tr",
"label": "Initial Model State Tr",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_model_state_tr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Tr`."
},
{
"name": "initial_model_state_t1",
"label": "Initial Model State T1",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_model_state_t1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T1`."
},
{
"name": "initial_pm9_t1_m3",
"label": "Initial PM9 T1 M3",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.initial_pm9_t1_m3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `pM9_T1_M3`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.species_labels"
},
{
"name": "tr_pm9_t1_m3",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.tr_pm9_t1_m3"
},
{
"name": "tr_pm9_t1",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.tr_pm9_t1"
},
{
"name": "tr_pm9",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.tr_pm9"
},
{
"name": "model_state_tr",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.model_state_tr"
},
{
"name": "model_state_t1",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.model_state_t1"
},
{
"name": "pm9_t1_m3",
"maps_to": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.pm9_t1_m3"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Vempati2007 Mmp9 Regulation Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model_state"
],
"from": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model_summary"
],
"from": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model_species_labels"
],
"from": "systemsbiology_sbml_vempati2007_mmp9_regulation_model7888000034_model.species_labels"
}
],
"package": "vempati2007-mmp9-regulation",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is the model described in the article: A biochemical model of matrix metalloproteinase 9 activation and inhibition. It can be used to explore systemsbiology vempati2007 mmp9 regulation model7888000034 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagevempati2007-mmp9-regulation
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother