Cappuccio2007 - Tumor-immune system interactions and determination of the optimal therapeutic protocol in immunotherapy Lab
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This ordinary differential equation model is the Panetta-Kirschner model of tumor-immune interactions is described in the publication:Cappuccio A, Castiglione F, Piccoli B.' Determination of the optim. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_effector_cells",
"label": "Initial Effector Cells",
"units": "native source value",
"default": 0.00001,
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.initial_effector_cells",
"description": "Initial Effector Cells. Sets the initial value of bundled SBML species `Effector_cells`."
},
{
"name": "initial_tumor_cells",
"label": "Initial Tumor Cells",
"units": "native source value",
"default": 0.00001,
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.initial_tumor_cells",
"description": "Initial Tumor Cells. Sets the initial value of bundled SBML species `Tumor_cells`."
},
{
"name": "initial_interleukin_2",
"label": "Initial Interleukin 2",
"units": "native source value",
"default": 0.00001,
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.initial_interleukin_2",
"description": "Initial Interleukin 2. Sets the initial value of bundled SBML species `IL_2`."
}
],
"outputs": [
{
"name": "effector_cells",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.effector_cells"
},
{
"name": "tumor_cells",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.tumor_cells"
},
{
"name": "interleukin_2",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.interleukin_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.species_labels"
}
]
},
"title": "Cappuccio2007 - Tumor-immune system interactions and determination of the optimal therapeutic protocol in immunotherapy Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model_state"
],
"from": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.state"
},
{
"to": [
"visualisation.immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model_summary"
],
"from": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model_species_labels"
],
"from": "immunology_sbml_cappuccio2007_tumor_immune_system_interactions_a_biomd0000001036_model.species_labels"
}
],
"package": "cappuccio2007-tumor-immune-system-interactions-and-dete-81d53ac9",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "This ordinary differential equation model is the Panetta-Kirschner model of tumor-immune interactions is described in the publication:Cappuccio A, Castiglione F, Piccoli B.' Determination of the optim. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagecappuccio2007-tumor-immune-system-interactions-and-dete-81d53ac9
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother