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Stefan2008 - calmodulin allostery An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed. It can be used to explore systemsbiology stefan2008 calmodulin allostery BioModels0000000183 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_ca_mkii",
"label": "Initial Ca Mkii",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_ca_mkii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_33`."
},
{
"name": "initial_model_state_ca",
"label": "Initial Model State Ca",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_model_state_ca",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_1`."
},
{
"name": "initial_pp2_b",
"label": "Initial PP2 B",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_pp2_b",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_50`."
},
{
"name": "initial_cam_t",
"label": "Initial Cam T",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_cam_t",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_17`."
},
{
"name": "initial_cam_r",
"label": "Initial Cam R",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_cam_r",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_0`."
},
{
"name": "initial_cam_t_ca4_abcd",
"label": "Initial Cam T CA4 Abcd",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.initial_cam_t_ca4_abcd",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `species_32`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.species_labels"
},
{
"name": "ca_mkii",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.ca_mkii"
},
{
"name": "model_state_ca",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.model_state_ca"
},
{
"name": "pp2_b",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.pp2_b"
},
{
"name": "cam_t",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.cam_t"
},
{
"name": "cam_r",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.cam_r"
},
{
"name": "cam_t_ca4_abcd",
"maps_to": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.cam_t_ca4_abcd"
}
]
},
"tags": [
"physiology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Stefan2008 Calmodulin Allostery Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model_state"
],
"from": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model_summary"
],
"from": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model_species_labels"
],
"from": "systemsbiology_sbml_stefan2008_calmodulin_allostery_biomd0000000183_model.species_labels"
}
],
"package": "stefan2008-calmodulin-allostery",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Stefan2008 - calmodulin allostery An allosteric model for calmodulin activation, in which binding to calcium facilitates the transition between a low-affinity [tense (T)] and a high-affinity [relaxed. It can be used to explore systemsbiology stefan2008 calmodulin allostery BioModels0000000183 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagestefan2008-calmodulin-allostery
Created2026-05-17
Updated2026-06-13
physiologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother