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Koo2013 Integrated Shear-Stress Induced NO Production Lab

About lab

One published Lab

Build with this Lab. Run it anywhere.

Use the same immutable release locally or through managed cloud execution, with its exact version and provenance preserved.

Preparing exact examples…

Koo et al. (2013) integrated endothelial mechanotransduction model combining shear-stress sensing, calcium influx, eNOS activation, and NO production into a single ODE system.

Manifest

{
  "description": "Koo et al. (2013) integrated endothelial mechanotransduction model combining shear-stress sensing, calcium influx, eNOS activation, and NO production into a single ODE system.",
  "io": {
    "inputs": [
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.integration_step",
        "name": "integration_step"
      },
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.stimulus_intensity",
        "name": "stimulus_intensity"
      }
    ],
    "outputs": [
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.active_eNOS",
        "name": "active_eNOS"
      },
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.cytosolic_calcium",
        "name": "cytosolic_calcium"
      },
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.nitric_oxide",
        "name": "nitric_oxide"
      },
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.state",
        "name": "state"
      },
      {
        "maps_to": "koo2013_integrated_shear_stress_no_production.summary",
        "name": "summary"
      }
    ]
  },
  "models": [
    {
      "alias": "koo2013_integrated_shear_stress_no_production",
      "parameters": {
        "integration_step": 1,
        "model_path": "data/BIOMD0000000468.xml"
      },
      "path": "models/core"
    },
    {
      "alias": "visualisation",
      "path": "models/visualisation"
    }
  ],
  "package": "koo2013-integrated",
  "runtime": {
    "communication_step": 10,
    "duration": 600,
    "initial_inputs": {}
  },
  "schema_version": "2.0",
  "title": "Koo2013 Integrated Shear-Stress Induced NO Production Lab",
  "version": "1.0.0",
  "wiring": [
    {
      "from": "koo2013_integrated_shear_stress_no_production.active_eNOS",
      "to": [
        "visualisation.koo2013_integrated_shear_stress_no_production_active_eNOS"
      ]
    },
    {
      "from": "koo2013_integrated_shear_stress_no_production.cytosolic_calcium",
      "to": [
        "visualisation.koo2013_integrated_shear_stress_no_production_cytosolic_calcium"
      ]
    },
    {
      "from": "koo2013_integrated_shear_stress_no_production.nitric_oxide",
      "to": [
        "visualisation.koo2013_integrated_shear_stress_no_production_nitric_oxide"
      ]
    },
    {
      "from": "koo2013_integrated_shear_stress_no_production.state",
      "to": [
        "visualisation.koo2013_integrated_shear_stress_no_production_state"
      ]
    },
    {
      "from": "koo2013_integrated_shear_stress_no_production.summary",
      "to": [
        "visualisation.koo2013_integrated_shear_stress_no_production_summary"
      ]
    }
  ]
}

Runtime

Duration600
Comms Step10

Runs

Total3
Completed3
Failed0

Metadata

Packagekoo2013-integrated
Created2026-05-04
Updated2026-06-13
biomechanicsendothelialshear-stressnitric-oxidemechanotransductionsbmlbiomodels_ebifaithfulvisualisationkoo2013other