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Source-faithful physiology lab for Potter, Greller, Cho, Nuttall, Stroup, Suva, Tobin, 2005. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"label": "Initial Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.initial_active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"description": "Initial value for Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ca`. Units: picomolar. Naming evidence: source metadata names `Ca` as `active parathyroid hormone-parathyroid hormone Type 1 receptor`.",
"accepted_units": [
"picomolar"
]
},
{
"name": "initial_inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"label": "Initial Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.initial_inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"description": "Initial value for Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ci`. Units: picomolar. Naming evidence: source metadata names `Ci` as `inactive parathyroid hormone-parathyroid hormone Type 1 receptor`.",
"accepted_units": [
"picomolar"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.variable_labels"
},
{
"name": "active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"label": "Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.active_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"description": "Active Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ca`. Units: picomolar. Naming evidence: source metadata names `Ca` as `active parathyroid hormone-parathyroid hormone Type 1 receptor`."
},
{
"name": "inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"label": "Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.inactive_parathyroid_hormone_parathyroid_hormone_type_1_receptor",
"description": "Inactive Parathyroid Hormone Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ci`. Units: picomolar. Naming evidence: source metadata names `Ci` as `inactive parathyroid hormone-parathyroid hormone Type 1 receptor`."
},
{
"name": "inactive_parathyroid_hormone_type_1_receptor",
"label": "Inactive Parathyroid Hormone Type 1 Receptor",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.inactive_parathyroid_hormone_type_1_receptor",
"description": "Inactive Parathyroid Hormone Type 1 Receptor. Maps to source symbol `Ri`. Units: picomolar. Naming evidence: source metadata names `Ri` as `inactive parathyroid hormone Type 1 receptor`."
},
{
"name": "active_pth1_r",
"label": "Active Pth1 R",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.active_pth1_r",
"description": "Active Pth1 R. Maps to source symbol `Ra`. Units: picomolar. Naming evidence: source metadata names `Ra` as `active PTH1R`."
},
{
"name": "parathyroid_hormone",
"label": "Parathyroid Hormone",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.parathyroid_hormone",
"description": "Parathyroid Hormone. Maps to source symbol `P`. Units: picomolar. Naming evidence: source metadata names `P` as `parathyroid hormone`."
},
{
"name": "kcl",
"label": "Kcl",
"maps_to": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.kcl",
"description": "Kcl. Maps to source symbol `kcl`. Units: first_order_rate_constant. Naming evidence: source symbol, component, or units provide a direct public name."
}
]
},
"title": "Potter2005 - Response Continuous Pulsatile Pth Dosing Mathematical Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model",
"parameters": {
"model_path": "data/potter_greller_cho_nuttall_stroup_suva_tobin_2005_a.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_state"
],
"from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.state"
},
{
"to": [
"visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_summary"
],
"from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_trajectory"
],
"from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model_variable_labels"
],
"from": "physiology_cellml_potter_greller_cho_nuttall_stroup_suva_tobin_200_pottergrellerchonuttallstroupsuvatobin2005_model.variable_labels"
}
],
"package": "potter2005-response-continuous-pulsatile-pth-dosing-mathematical",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.1",
"description": "Source-faithful physiology lab for Potter, Greller, Cho, Nuttall, Stroup, Suva, Tobin, 2005. Public controls and outputs are mapped to real source symbols for bone and endocrine physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagepotter2005-response-continuous-pulsatile-pth-dosing-mathematical
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother