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Fabrizio Capuani, Alexia Conte, Elisabetta Argenzio, Luca Marchetti, Corrado Priami, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund & Andrea Ciliberto. It can be used to explore systemsbiology capuani2015 binding of cbl and dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_grb2",
"label": "Initial Grb2",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_grb2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Grb2`."
},
{
"name": "initial_rc00_uu",
"label": "Initial Rc00 Uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_rc00_uu",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Rc00UU`."
},
{
"name": "initial_di00_uu",
"label": "Initial Di00 Uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_di00_uu",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Di00UU`."
},
{
"name": "initial_r00_uu",
"label": "Initial R00 Uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_r00_uu",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `R00UU`."
},
{
"name": "initial_model_state_cg",
"label": "Initial Model State Cg",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_model_state_cg",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CG`."
},
{
"name": "initial_model_state_cbl",
"label": "Initial Model State Cbl",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.initial_model_state_cbl",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Cbl`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.species_labels"
},
{
"name": "grb2",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.grb2"
},
{
"name": "rc00_uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.rc00_uu"
},
{
"name": "di00_uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.di00_uu"
},
{
"name": "r00_uu",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.r00_uu"
},
{
"name": "model_state_cg",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.model_state_cg"
},
{
"name": "cbl",
"maps_to": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.cbl"
}
]
},
"tags": [
"signaling",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Capuani2015 Binding Of Cbl And Grb2 To Egfr Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model_state"
],
"from": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model_summary"
],
"from": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model_species_labels"
],
"from": "systemsbiology_sbml_capuani2015_binding_of_cbl_and_grb2_to_egfr_earl_biomd0000000595_model.species_labels"
}
],
"package": "capuani2015-binding-of-cbl-and-grb2-to-egfr",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Fabrizio Capuani, Alexia Conte, Elisabetta Argenzio, Luca Marchetti, Corrado Priami, Simona Polo, Pier Paolo Di Fiore, Sara Sigismund & Andrea Ciliberto. It can be used to explore systemsbiology capuani2015 binding of cbl and dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagecapuani2015-binding-of-cbl-and-grb2-to-egfr
Created2026-05-17
Updated2026-06-13
signalingsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother