Integrated Model of DNA Damage Response and p53 Signaling in ATM/ATR-Deficient Ataxia Telangiectasia: Exploring the Therapeutic Roles of Possible repurposed drugs Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_source_defined_ck2_state",
        "label": "Initial source-defined CK2 state",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.initial_source_defined_ck2_state",
        "description": "Initial level of source-defined CK2 state. Maps to SBML symbol `CK2`; exposed as a traceable initial-condition perturbation."
      },
      {
        "name": "initial_keap1",
        "label": "Initial KEAP1",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.initial_keap1",
        "description": "Initial level of KEAP1. Maps to SBML symbol `KEAP1`; exposed as a traceable initial-condition perturbation."
      },
      {
        "name": "initial_omaveloxolone",
        "label": "Initial Omaveloxolone",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.initial_omaveloxolone",
        "description": "Initial level of Omaveloxolone. Maps to SBML symbol `Omaveloxolone`; exposed as a traceable initial-condition perturbation."
      }
    ],
    "outputs": [
      {
        "name": "atm_inactive",
        "label": "ATM Inactive",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.atm_inactive",
        "description": "ATM Inactive. Maps to SBML symbol `ATM_inactive` and is emitted in native SBML units."
      },
      {
        "name": "atm_active",
        "label": "ATM active",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.atm_active",
        "description": "ATM active. Maps to SBML symbol `ATM_active` and is emitted in native SBML units."
      },
      {
        "name": "atr_inactive",
        "label": "ATR Inactive",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.atr_inactive",
        "description": "ATR Inactive. Maps to SBML symbol `ATR_inactive` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "checkpoint-signaling",
    "pharmacology"
  ],
  "title": "Integrated Model of DNA Damage Response and p53 Signaling in ATM/ATR-Deficient Ataxia Telangiectasia: Exploring the Therapeutic Roles of Possible repurposed drugs Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model_state"
      ],
      "from": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model_summary"
      ],
      "from": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model_species_labels"
      ],
      "from": "signaling_sbml_integrated_model_of_dna_damage_response_and_p53_model2503190002_model.species_labels"
    }
  ],
  "package": "integrated-model-of-dna-damage-response-and-p53",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "Clean Biosimulant lab for systems signaling model: Integrated Model of DNA Damage Response and p53 Signaling in ATM/ATR-Deficient Ataxia Telangiectasia: Exploring the Therapeutic Roles of Possible repurposed drugs. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}