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This a model from the article: Modeling immunotherapy of the tumor-immune interaction. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor",
"label": "Initial Tumor",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.initial_tumor",
"description": "Initial Tumor. Sets the initial value of bundled SBML species `Tumor`."
},
{
"name": "initial_immune_cells",
"label": "Initial Immune Cells",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.initial_immune_cells",
"description": "Initial Immune Cells. Sets the initial value of bundled SBML species `Immune_cells`."
},
{
"name": "initial_interleukin_2",
"label": "Initial Interleukin 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.initial_interleukin_2",
"description": "Initial Interleukin 2. Sets the initial value of bundled SBML species `IL2`."
}
],
"outputs": [
{
"name": "tumor",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.tumor"
},
{
"name": "immune_cells",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.immune_cells"
},
{
"name": "source",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.source"
},
{
"name": "sink",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.sink"
},
{
"name": "interleukin_2",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.interleukin_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.species_labels"
}
]
},
"title": "Kirschner1998 Immunotherapy Tumour Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model_state"
],
"from": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.state"
},
{
"to": [
"visualisation.immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model_summary"
],
"from": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model_species_labels"
],
"from": "immunology_sbml_kirschner1998_immunotherapy_tumour_biomd0000000732_model.species_labels"
}
],
"package": "kirschner1998-immunotherapy-tumour",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This a model from the article: Modeling immunotherapy of the tumor-immune interaction. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagekirschner1998-immunotherapy-tumour
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother