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Proctor2017- Role of microRNAs inosteoarthritis (miR140-SMAD3 double negative feedback) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNA. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tg_fb_a",
"label": "Initial Tg Fb A",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_tg_fb_a",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGFb_A`."
},
{
"name": "initial_tg_fb_i",
"label": "Initial Tg Fb I",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_tg_fb_i",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `TGFb_I`."
},
{
"name": "initial_mi_r140",
"label": "Initial Mi R140",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_mi_r140",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140`."
},
{
"name": "initial_smad3",
"label": "Initial Smad3",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_smad3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SMAD3`."
},
{
"name": "initial_mi_r140_smad3_mrna",
"label": "Initial Mi R140 Smad3 MRNA",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_mi_r140_smad3_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `miR140_SMAD3_mRNA`."
},
{
"name": "initial_smad3_mrna",
"label": "Initial Smad3 MRNA",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.initial_smad3_mrna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SMAD3_mRNA`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.species_labels"
},
{
"name": "tg_fb_a",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.tg_fb_a"
},
{
"name": "tg_fb_i",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.tg_fb_i"
},
{
"name": "mi_r140",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.mi_r140"
},
{
"name": "smad3",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.smad3"
},
{
"name": "mi_r140_smad3_mrna",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.mi_r140_smad3_mrna"
},
{
"name": "smad3_mrna",
"maps_to": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.smad3_mrna"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Proctor2017 Role Of Micrornas In Osteoarthritis 8 Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_state"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_summary"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model_species_labels"
],
"from": "systemsbiology_sbml_proctor2017_role_of_micrornas_in_osteoarthritis_model1705170000_model.species_labels"
}
],
"package": "proctor2017-role-of-micrornas-in-osteoarthritis-8",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Proctor2017- Role of microRNAs inosteoarthritis (miR140-SMAD3 double negative feedback) This model is described in the article: Computer simulation models as a tool to investigate the role of microRNA. It can be used to explore systemsbiology proctor2017 role of micrornas in dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageproctor2017-role-of-micrornas-in-osteoarthritis-8
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother