Reddyhoff2015 - Acetaminophen metabolism and toxicity Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_sulphate_paps",
        "units": "native SBML value",
        "default": 1.325e-14,
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.initial_sulphate_paps",
        "description": "Initial condition for sulphate paps. Maps to bundled SBML symbol `Sulphate__PAPS`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_glutathione",
        "units": "native SBML value",
        "default": 6.87e-15,
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.initial_glutathione",
        "description": "Initial condition for glutathione. Maps to bundled SBML symbol `GSH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_3",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.initial_drug_metabolism_state_3",
        "description": "Initial condition for drug metabolism state 3. Maps to bundled SBML symbol `NAPQI`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_4",
        "units": "native SBML value",
        "default": 1.32e-13,
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.initial_drug_metabolism_state_4",
        "description": "Initial condition for drug metabolism state 4. Maps to bundled SBML symbol `Paracetamol_APAP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_5",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.initial_drug_metabolism_state_5",
        "description": "Initial condition for drug metabolism state 5. Maps to bundled SBML symbol `Protein_adducts`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "sulphate_paps",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.sulphate_paps"
      },
      {
        "name": "glutathione",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.glutathione"
      },
      {
        "name": "drug_metabolism_state_3",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.drug_metabolism_state_3"
      },
      {
        "name": "drug_metabolism_state_4",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.drug_metabolism_state_4"
      },
      {
        "name": "drug_metabolism_state_5",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.drug_metabolism_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.observable_labels"
      }
    ]
  },
  "title": "Reddyhoff2015 - Acetaminophen metabolism and toxicity Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model",
      "parameters": {
        "model_path": "data/BIOMD0000000609.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model_observable_values"
      ],
      "from": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model_run_summary"
      ],
      "from": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model_observable_labels"
      ],
      "from": "metabolism_sbml_reddyhoff2015_acetaminophen_metabolism_and_toxic_biomd0000000609_model.observable_labels"
    }
  ],
  "package": "reddyhoff2015-acetaminophen-metabolism-and-toxicity",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Reddyhoff2015 - Acetaminophen metabolism and toxicity This model examines acetaminophen metabolism and related hepatotoxicity. Multiple pathways associated with APAP metabolism has been included in th.",
  "schema_version": "2.0"
}