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Source-faithful physiology lab for Tyson, Hong, Thron, Novak, 1999. Public controls and outputs are mapped to real source symbols for oscillatory physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_m_rna_concentration",
"label": "Initial M RNA Concentration",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.initial_m_rna_concentration",
"description": "Initial value for M RNA Concentration. Maps to source symbol `M`. Units: nanomolar. Naming evidence: source metadata names `M` as `mRNA concentration`.",
"accepted_units": [
"nanomolar"
]
},
{
"name": "initial_total_protein_concentration",
"label": "Initial Total Protein Concentration",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.initial_total_protein_concentration",
"description": "Initial value for Total Protein Concentration. Maps to source symbol `Pt`. Units: nanomolar. Naming evidence: source metadata names `Pt` as `total protein concentration`.",
"accepted_units": [
"nanomolar"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.variable_labels"
},
{
"name": "m_rna_concentration",
"label": "M RNA Concentration",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.m_rna_concentration",
"description": "M RNA Concentration. Maps to source symbol `M`. Units: nanomolar. Naming evidence: source metadata names `M` as `mRNA concentration`."
},
{
"name": "total_protein_concentration",
"label": "Total Protein Concentration",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.total_protein_concentration",
"description": "Total Protein Concentration. Maps to source symbol `Pt`. Units: nanomolar. Naming evidence: source metadata names `Pt` as `total protein concentration`."
},
{
"name": "keq",
"label": "Keq",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.keq",
"description": "Keq. Maps to source symbol `Keq`. Units: per_nanomolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "kp1",
"label": "Kp1",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.kp1",
"description": "Kp1. Maps to source symbol `kp1`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "kp2",
"label": "Kp2",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.kp2",
"description": "Kp2. Maps to source symbol `kp2`. Units: flux. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "model_parameter_q",
"label": "Model Parameter Q (source q)",
"maps_to": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.model_parameter_q",
"description": "Model Parameter Q (source q). Maps to source symbol `q`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
}
]
},
"title": "Tyson1999 - Simple Mathematical Circadian Rhythms Based Dimerisation Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model",
"parameters": {
"model_path": "data/tyson_hong_thron_novak_1999.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_state"
],
"from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.state"
},
{
"to": [
"visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_summary"
],
"from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_trajectory"
],
"from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model_variable_labels"
],
"from": "physiology_cellml_tyson_hong_thron_novak_1999_tysonhongthronnovak1999_model.variable_labels"
}
],
"package": "tyson1999-simple-mathematical-circadian-rhythms-based-d-ccbea232",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Tyson, Hong, Thron, Novak, 1999. Public controls and outputs are mapped to real source symbols for oscillatory physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagetyson1999-simple-mathematical-circadian-rhythms-based-d-ccbea232
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother