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This is the model of the RTC3 counter described in the article: Synthetic gene networks that count. Friedland AE, Lu TK, Wang X, Shi D, Church G, Collins JJ.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_pgfp",
"label": "Initial Pgfp",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_pgfp",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `pGFP`."
},
{
"name": "initial_mt7cr",
"label": "Initial Mt7cr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_mt7cr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mT7cr`."
},
{
"name": "initial_mgf_pcr",
"label": "Initial Mgf Pcr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_mgf_pcr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mGFPcr`."
},
{
"name": "initial_model_state_pt7",
"label": "Initial Model State PT7",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_model_state_pt7",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `pT7`."
},
{
"name": "initial_ta_rna",
"label": "Initial Ta RNA",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_ta_rna",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `taRNA`."
},
{
"name": "initial_mt3cr",
"label": "Initial Mt3cr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.initial_mt3cr",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mT3cr`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.species_labels"
},
{
"name": "pgfp",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.pgfp"
},
{
"name": "mt7cr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.mt7cr"
},
{
"name": "mgf_pcr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.mgf_pcr"
},
{
"name": "pt7",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.pt7"
},
{
"name": "ta_rna",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.ta_rna"
},
{
"name": "mt3cr",
"maps_to": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.mt3cr"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Friedland2009 Ara Rtc3 Counter Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model_state"
],
"from": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model_summary"
],
"from": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model_species_labels"
],
"from": "systemsbiology_sbml_friedland2009_ara_rtc3_counter_biomd0000000301_model.species_labels"
}
],
"package": "friedland2009-ara-rtc3-counter",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is the model of the RTC3 counter described in the article: Synthetic gene networks that count. Friedland AE, Lu TK, Wang X, Shi D, Church G, Collins JJ.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagefriedland2009-ara-rtc3-counter
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother