Elias2025 - Physiologically based pharmacokinetics (PBPK) model glimepiride Lab

{
  "io": {
    "inputs": [
      {
        "name": "oral_glimepiride_dose_mg",
        "label": "Oral Glimepiride Dose Mg",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.oral_glimepiride_dose_mg"
      },
      {
        "name": "iv_glimepiride_bolus_mg",
        "label": "IV Glimepiride Bolus Mg",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.iv_glimepiride_bolus_mg"
      },
      {
        "name": "glimepiride_infusion_rate_mg_per_min",
        "label": "Glimepiride Infusion Rate Mg Per Min",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_infusion_rate_mg_per_min"
      },
      {
        "name": "cyp2c9_activity_scale",
        "label": "CYP2C9 Activity Scale",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.cyp2c9_activity_scale"
      },
      {
        "name": "intestinal_absorption_scale",
        "label": "Intestinal Absorption Scale",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.intestinal_absorption_scale"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.species_labels"
      },
      {
        "name": "glimepiride_liver_plasma",
        "label": "Glimepiride Liver Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_liver_plasma"
      },
      {
        "name": "glimepiride_arterial_plasma",
        "label": "Glimepiride Arterial Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_arterial_plasma"
      },
      {
        "name": "glimepiride_venous_plasma",
        "label": "Glimepiride Venous Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_venous_plasma"
      },
      {
        "name": "glimepiride_kidney_plasma",
        "label": "Glimepiride Kidney Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_kidney_plasma"
      },
      {
        "name": "glimepiride_gut_plasma",
        "label": "Glimepiride Gut Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.glimepiride_gut_plasma"
      },
      {
        "name": "m1_liver_plasma",
        "label": "M1 Liver Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.m1_liver_plasma"
      },
      {
        "name": "m1_arterial_plasma",
        "label": "M1 Arterial Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.m1_arterial_plasma"
      },
      {
        "name": "m1_venous_plasma",
        "label": "M1 Venous Plasma",
        "maps_to": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.m1_venous_plasma"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "pbpk",
    "pharmacokinetics",
    "physiology",
    "endocrine",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Elias2025 - Physiologically based pharmacokinetics (PBPK) model glimepiride Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model",
      "parameters": {
        "model_path": "data/MODEL2510140001.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model_state"
      ],
      "from": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model_summary"
      ],
      "from": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model_species_labels"
      ],
      "from": "pharmacology_sbml_elias2025_physiologically_based_pharmacokinetics_model2510140001_model.species_labels"
    }
  ],
  "package": "elias2025-glimepiride-pbpk",
  "runtime": {
    "duration": 24,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Pharmacology Elias2025Physiologically Based Pharmacokinetics Model2510140001Model models core biological dynamics as a OTHER simulation curated from biomodels_ebi (biomodels_ebi:MODEL2510140001), focused on pha. When you run it, you can track state over time and compare response patterns across parameter settings.",
  "schema_version": "2.0"
}