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This model is based on the publication:Coletti R, Leonardelli L, Parolo S, Marchetti L. A QSP model of prostate cancer immunotherapy to identify effective combination therapies.
Manifest
{
"io": {
"inputs": [
{
"name": "k_anti_il_source_parameter",
"label": "K antiIl source parameter",
"units": "native SBML value",
"default": 0.714,
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.k_anti_il_source_parameter",
"description": "K antiIl source parameter. Maps to bundled SBML parameter `k_antiIl`."
}
],
"outputs": [
{
"name": "x_1",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.x_1",
"description": "X 1 observable. Maps to SBML symbol `X_1`."
},
{
"name": "a",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.a",
"description": "A observable. Maps to SBML symbol `A`."
},
{
"name": "d_m",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.d_m",
"description": "D m observable. Maps to SBML symbol `D_m`."
},
{
"name": "c_2",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.c_2",
"description": "C 2 observable. Maps to SBML symbol `C_2`."
},
{
"name": "i_2",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.i_2",
"description": "I 2 observable. Maps to SBML symbol `I_2`."
},
{
"name": "normal_cells",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.normal_cells",
"description": "N observable. Maps to SBML symbol `N`."
},
{
"name": "state",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"curated",
"drug-response",
"faithful",
"immunology",
"immunotherapy",
"microenvironment",
"oncology",
"pharmacology",
"physiology",
"sbml",
"signal-transduction",
"signaling",
"systemsbiology",
"tumor-growth"
],
"title": "Coletti2020 - QSP model of prostate cancer immunotherapy Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_state"
],
"from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.state"
},
{
"to": [
"visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_summary"
],
"from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model_species_labels"
],
"from": "oncology_sbml_coletti2020_qsp_model_of_prostate_cancer_immunot_model2109110002_model.species_labels"
}
],
"package": "coletti2020-qsp-of-prostate-cancer-immunotherapy",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This model is based on the publication:Coletti R, Leonardelli L, Parolo S, Marchetti L. A QSP model of prostate cancer immunotherapy to identify effective combination therapies.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagecoletti2020-qsp-of-prostate-cancer-immunotherapy
Created2026-05-16
Updated2026-06-13
biomodels_ebicurateddrug-responsefaithfulimmunologyimmunotherapymicroenvironmentoncologypharmacologyphysiologysbmlsignal-transductionsignalingsystemsbiologytumor-growthvisualisationother