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Single-model lab wrapper for Novak1993 - Cell cycle M-phase control. Novak1993 - Cell cycle M-phase control The model reproduces Figure 9 of the paper. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "cdc2",
"label": "Cdc2",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cdc2",
"description": "Controls Cdc2 in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cdc2`."
},
{
"name": "cdc25",
"label": "Cdc25",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cdc25",
"description": "Controls Cdc25 in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cdc25`."
},
{
"name": "wee1",
"label": "Wee1",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.wee1",
"description": "Controls Wee1 in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.wee1`."
},
{
"name": "intermediary_enzyme",
"label": "Intermediary Enzyme",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.intermediary_enzyme",
"description": "Controls Intermediary Enzyme in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.intermediary_enzyme`."
},
{
"name": "ubiquitin_conjugating_enzyme",
"label": "Ubiquitin Conjugating Enzyme",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.ubiquitin_conjugating_enzyme",
"description": "Controls Ubiquitin Conjugating Enzyme in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.ubiquitin_conjugating_enzyme`."
}
],
"outputs": [
{
"name": "cyclin",
"label": "Cyclin",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cyclin",
"description": "Tracks Cyclin in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cyclin`."
},
{
"name": "cyclin_cdc2_dimer",
"label": "Cyclin Cdc2 Dimer",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cyclin_cdc2_dimer",
"description": "Tracks Cyclin Cdc2 Dimer in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.cyclin_cdc2_dimer`."
},
{
"name": "phosphorylated_dimer",
"label": "Phosphorylated Dimer",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_dimer",
"description": "Tracks Phosphorylated Dimer in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_dimer`."
},
{
"name": "tyr15_phosphorylated_dimer",
"label": "Tyr15 Phosphorylated Dimer",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.tyr15_phosphorylated_dimer",
"description": "Tracks Tyr15 Phosphorylated Dimer in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.tyr15_phosphorylated_dimer`."
},
{
"name": "phosphorylated_p_dimer",
"label": "Phosphorylated P Dimer",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_p_dimer",
"description": "Tracks Phosphorylated P Dimer in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_p_dimer`."
},
{
"name": "phosphorylated_cdc25",
"label": "Phosphorylated Cdc25",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_cdc25",
"description": "Tracks Phosphorylated Cdc25 in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_cdc25`."
},
{
"name": "phosphorylated_wee1",
"label": "Phosphorylated Wee1",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_wee1",
"description": "Tracks Phosphorylated Wee1 in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_wee1`."
},
{
"name": "phosphorylated_ie",
"label": "Phosphorylated IE",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_ie",
"description": "Tracks Phosphorylated IE in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.phosphorylated_ie`."
},
{
"name": "ubiquitin_conjugating_enzyme",
"label": "Ubiquitin Conjugating Enzyme",
"maps_to": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.ubiquitin_conjugating_enzyme",
"description": "Tracks Ubiquitin Conjugating Enzyme in the lab model via `cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.ubiquitin_conjugating_enzyme`."
}
]
},
"title": "Novak1993 - Cell cycle M-phase control Lab",
"models": [
{
"path": "models/core",
"alias": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model_state"
],
"from": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.state"
},
{
"to": [
"visualisation.cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model_summary"
],
"from": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.summary"
},
{
"to": [
"visualisation.cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model_species_labels"
],
"from": "cellcycle_sbml_novak1993_cell_cycle_m_phase_control_biomd0000000107_model.species_labels"
}
],
"package": "novak1993-m-phase-control",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Single-model lab wrapper for Novak1993 - Cell cycle M-phase control. Novak1993 - Cell cycle M-phase control The model reproduces Figure 9 of the paper. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagenovak1993-m-phase-control
Created2026-05-15
Updated2026-06-13
cellcyclesbmlbiomodels_ebifaithfulvisualisationother