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This is the standard model described in the article: Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. Rehm M, Huber HJ, Dussmann H, Prehn JH.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cytochrome_c_in_mitochondrium",
"label": "Initial Cytochrome C In Mitochondrium",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_cytochrome_c_in_mitochondrium",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CytC_mit`."
},
{
"name": "initial_smac_in_mitochondrium",
"label": "Initial Smac In Mitochondrium",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_smac_in_mitochondrium",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SMAC_mito`."
},
{
"name": "initial_casp3_substrate",
"label": "Initial Casp3 Substrate",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_casp3_substrate",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Substrate`."
},
{
"name": "initial_pro_casp3",
"label": "Initial Pro Casp3",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_pro_casp3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PC3`."
},
{
"name": "initial_pro_casp9",
"label": "Initial Pro Casp9",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_pro_casp9",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `PC9`."
},
{
"name": "initial_cytosolic_cytochrome_c",
"label": "Initial Cytosolic Cytochrome C",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.initial_cytosolic_cytochrome_c",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CytC_cell`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.species_labels"
},
{
"name": "cytochrome_c_in_mitochondrium",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.cytochrome_c_in_mitochondrium"
},
{
"name": "smac_in_mitochondrium",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.smac_in_mitochondrium"
},
{
"name": "casp3_substrate",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.casp3_substrate"
},
{
"name": "pro_casp3",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.pro_casp3"
},
{
"name": "pro_casp9",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.pro_casp9"
},
{
"name": "cytosolic_cytochrome_c",
"maps_to": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.cytosolic_cytochrome_c"
}
]
},
"tags": [
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Rehm2006 Caspase Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model_state"
],
"from": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model_summary"
],
"from": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model_species_labels"
],
"from": "systemsbiology_sbml_rehm2006_caspase_biomd0000000256_model.species_labels"
}
],
"package": "rehm2006-caspase",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is the standard model described in the article: Systems analysis of effector caspase activation and its control by X-linked inhibitor of apoptosis protein. Rehm M, Huber HJ, Dussmann H, Prehn JH.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagerehm2006-caspase
Created2026-05-17
Updated2026-06-13
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother