Pappalardo2016 - PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_ras_inactive",
        "label": "RasInactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_ras_inactive",
        "description": "Initial RasInactive. Sets the initial value of bundled SBML symbol `species_5`."
      },
      {
        "name": "initial_raf1_inactive",
        "label": "Raf1Inactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_raf1_inactive",
        "description": "Initial Raf1Inactive. Sets the initial value of bundled SBML symbol `species_7`."
      },
      {
        "name": "initial_erk_inactive",
        "label": "ErkInactive",
        "units": "native SBML value",
        "default": 600000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_erk_inactive",
        "description": "Initial ErkInactive. Sets the initial value of bundled SBML symbol `species_11`."
      },
      {
        "name": "initial_pi3_kinactive",
        "label": "PI3KInactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_pi3_kinactive",
        "description": "Initial PI3KInactive. Sets the initial value of bundled SBML symbol `species_15`."
      },
      {
        "name": "initial_akt_inactive",
        "label": "AktInactive",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_akt_inactive",
        "description": "Initial AktInactive. Sets the initial value of bundled SBML symbol `species_17`."
      },
      {
        "name": "initial_braf_mutated",
        "label": "BRafMutated",
        "units": "native SBML value",
        "default": 120000,
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.initial_braf_mutated",
        "description": "Initial BRafMutated. Sets the initial value of bundled SBML symbol `bRafMutated`."
      }
    ],
    "outputs": [
      {
        "name": "ras_inactive",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.ras_inactive",
        "description": "RasInactive observable. Maps to SBML symbol `species_5`."
      },
      {
        "name": "raf1_inactive",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.raf1_inactive",
        "description": "Raf1Inactive observable. Maps to SBML symbol `species_7`."
      },
      {
        "name": "erk_inactive",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.erk_inactive",
        "description": "ErkInactive observable. Maps to SBML symbol `species_11`."
      },
      {
        "name": "pi3_kinactive",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.pi3_kinactive",
        "description": "PI3KInactive observable. Maps to SBML symbol `species_15`."
      },
      {
        "name": "akt_inactive",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.akt_inactive",
        "description": "AktInactive observable. Maps to SBML symbol `species_17`."
      },
      {
        "name": "braf_mutated",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.braf_mutated",
        "description": "BRafMutated observable. Maps to SBML symbol `bRafMutated`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Pappalardo2016 - PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model_state"
      ],
      "from": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model_summary"
      ],
      "from": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model_species_labels"
      ],
      "from": "oncology_sbml_pappalardo2016_pi3k_akt_and_mapk_signaling_pathw_biomd0000000666_model.species_labels"
    }
  ],
  "package": "pappalardo2016-pi3k-akt-and-mapk-signaling-pathways-in-fbda4b3c",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Pappalardo2016 - PI3K/AKT and MAPK SignalingPathways in Melanoma Cancer This model is described in the article: Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}