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Koo2013 Shear-Stress Induced NO Production Lab

About lab

One published Lab

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Use the same immutable release locally or through managed cloud execution, with its exact version and provenance preserved.

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Koo et al. (2013) model of nitric oxide (NO) production downstream of shear-stress-driven calcium and eNOS activation in endothelial cells.

Manifest

{
  "io": {
    "inputs": [
      {
        "name": "cytosolic_calcium",
        "maps_to": "koo2013_shear_stress_no_production.cytosolic_calcium"
      },
      {
        "name": "integration_step",
        "maps_to": "koo2013_shear_stress_no_production.integration_step"
      }
    ],
    "outputs": [
      {
        "name": "active_eNOS",
        "maps_to": "koo2013_shear_stress_no_production.active_eNOS"
      },
      {
        "name": "nitric_oxide",
        "maps_to": "koo2013_shear_stress_no_production.nitric_oxide"
      },
      {
        "name": "state",
        "maps_to": "koo2013_shear_stress_no_production.state"
      },
      {
        "name": "summary",
        "maps_to": "koo2013_shear_stress_no_production.summary"
      }
    ]
  },
  "title": "Koo2013 Shear-Stress Induced NO Production Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "koo2013_shear_stress_no_production",
      "parameters": {
        "model_path": "data/BIOMD0000000467.xml",
        "integration_step": 1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.koo2013_shear_stress_no_production_active_eNOS"
      ],
      "from": "koo2013_shear_stress_no_production.active_eNOS"
    },
    {
      "to": [
        "visualisation.koo2013_shear_stress_no_production_nitric_oxide"
      ],
      "from": "koo2013_shear_stress_no_production.nitric_oxide"
    },
    {
      "to": [
        "visualisation.koo2013_shear_stress_no_production_state"
      ],
      "from": "koo2013_shear_stress_no_production.state"
    },
    {
      "to": [
        "visualisation.koo2013_shear_stress_no_production_summary"
      ],
      "from": "koo2013_shear_stress_no_production.summary"
    }
  ],
  "package": "koo2013-no-production",
  "runtime": {
    "duration": 600,
    "initial_inputs": {},
    "communication_step": 10
  },
  "version": "1.0.0",
  "description": "Koo et al. (2013) model of nitric oxide (NO) production downstream of shear-stress-driven calcium and eNOS activation in endothelial cells.",
  "schema_version": "2.0"
}

Runtime

Duration600
Comms Step10

Runs

Total4
Completed4
Failed0

Metadata

Packagekoo2013-no-production
Created2026-05-04
Updated2026-06-13
biomechanicsendothelialshear-stressnitric-oxidemechanotransductionsbmlbiomodels_ebifaithfulvisualisationkoo2013other