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The model reproduces the time profiles of p27, E2F and aE/cdk2 as depicted in Figure 5 c of the paper. It can be used to explore systemsbiology aguda1999 cellcycle BioModels0000000169 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_p27",
"label": "Initial Model State P27",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_model_state_p27",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y7_1`."
},
{
"name": "initial_model_state_p16",
"label": "Initial Model State P16",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_model_state_p16",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y10_1`."
},
{
"name": "initial_p_rb_e2_f",
"label": "Initial P Rb E2 F",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb_e2_f",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y3_1`."
},
{
"name": "initial_cyc_e_cdk2_p27",
"label": "Initial Cyc E Cdk2 P27",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_cyc_e_cdk2_p27",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y8_1`."
},
{
"name": "initial_p_rb",
"label": "Initial P Rb",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y5_1`."
},
{
"name": "initial_p_rb_p",
"label": "Initial P Rb P",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.initial_p_rb_p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Y11_1`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.species_labels"
},
{
"name": "p27",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p27"
},
{
"name": "p16",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p16"
},
{
"name": "p_rb_e2_f",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb_e2_f"
},
{
"name": "cyc_e_cdk2_p27",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.cyc_e_cdk2_p27"
},
{
"name": "p_rb",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb"
},
{
"name": "p_rb_p",
"maps_to": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.p_rb_p"
}
]
},
"tags": [
"cellcycle",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Aguda1999 Cellcycle Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_state"
],
"from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_summary"
],
"from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model_species_labels"
],
"from": "systemsbiology_sbml_aguda1999_cellcycle_biomd0000000169_model.species_labels"
}
],
"package": "aguda1999-cellcycle",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "The model reproduces the time profiles of p27, E2F and aE/cdk2 as depicted in Figure 5 c of the paper. It can be used to explore systemsbiology aguda1999 cellcycle BioModels0000000169 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageaguda1999-cellcycle
Created2026-05-17
Updated2026-06-13
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother