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Using scaling from PhysB modelBlood flow in L/hrCompartments in KgBaseline as ~0.003nM Free E2 in Blood_venous E2 biosynthesis rate constant = 2 E2 biosynthesis species = 1nMCLeh = 5CLint = metabolic. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_metabolic_pathway_state_1",
"units": "native SBML value",
"default": 1,
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.initial_metabolic_pathway_state_1",
"description": "Initial condition for metabolic pathway state 1. Maps to bundled SBML symbol `Faeces`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_2",
"units": "native SBML value",
"default": 3001.00000000002,
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.initial_metabolic_pathway_state_2",
"description": "Initial condition for metabolic pathway state 2. Maps to bundled SBML symbol `count`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_3",
"units": "native SBML value",
"default": -2999.00000000002,
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.initial_metabolic_pathway_state_3",
"description": "Initial condition for metabolic pathway state 3. Maps to bundled SBML symbol `default_0`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_4",
"units": "native SBML value",
"default": 0.0209437464725829,
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.initial_metabolic_pathway_state_4",
"description": "Initial condition for metabolic pathway state 4. Maps to bundled SBML symbol `s16`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_5",
"units": "native SBML value",
"default": 39.4491907670147,
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.initial_metabolic_pathway_state_5",
"description": "Initial condition for metabolic pathway state 5. Maps to bundled SBML symbol `s18`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
}
],
"outputs": [
{
"name": "metabolic_pathway_state_1",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.metabolic_pathway_state_1"
},
{
"name": "metabolic_pathway_state_2",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.metabolic_pathway_state_2"
},
{
"name": "metabolic_pathway_state_3",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.metabolic_pathway_state_3"
},
{
"name": "metabolic_pathway_state_4",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.metabolic_pathway_state_4"
},
{
"name": "metabolic_pathway_state_5",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.metabolic_pathway_state_5"
},
{
"name": "observable_values",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.observable_values"
},
{
"name": "run_summary",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.run_summary"
},
{
"name": "observable_labels",
"maps_to": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.observable_labels"
}
]
},
"title": "Sier2017_E2_combined Lab",
"models": [
{
"path": "models/core",
"alias": "metabolism_sbml_sier2017_e2_combined_model1711210002_model",
"parameters": {
"model_path": "data/MODEL1711210002.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.metabolism_sbml_sier2017_e2_combined_model1711210002_model_observable_values"
],
"from": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.observable_values"
},
{
"to": [
"visualisation.metabolism_sbml_sier2017_e2_combined_model1711210002_model_run_summary"
],
"from": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.run_summary"
},
{
"to": [
"visualisation.metabolism_sbml_sier2017_e2_combined_model1711210002_model_observable_labels"
],
"from": "metabolism_sbml_sier2017_e2_combined_model1711210002_model.observable_labels"
}
],
"package": "sier2017-e2-combined",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Using scaling from PhysB modelBlood flow in L/hrCompartments in KgBaseline as ~0.003nM Free E2 in Blood_venous E2 biosynthesis rate constant = 2 E2 biosynthesis species = 1nMCLeh = 5CLint = metabolic. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagesier2017-e2-combined
Created2026-05-15
Updated2026-06-13
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisationother