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Mathematical model of blood coagulation to simulate factor IIa, Va and Xa concentration profiles. Publication also illustrates the effect of hirudin on factor IIa, Va and Xa generation.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_xa_atiii",
"label": "Initial Xa Atiii",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_xa_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_ATIII`."
},
{
"name": "initial_va_inactive",
"label": "Initial Va Inactive",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_va_inactive",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Va_inactive`."
},
{
"name": "initial_va_xa",
"label": "Initial Va Xa",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_va_xa",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Va_Xa`."
},
{
"name": "initial_i_ia_hirudin",
"label": "Initial I Ia Hirudin",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_i_ia_hirudin",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IIa_Hirudin`."
},
{
"name": "initial_i_ia_atiii",
"label": "Initial I Ia Atiii",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_i_ia_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `IIa_ATIII`."
},
{
"name": "initial_apc_inactive",
"label": "Initial Apc Inactive",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.initial_apc_inactive",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `APC_inactive`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.species_labels"
},
{
"name": "xa_atiii",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.xa_atiii"
},
{
"name": "va_inactive",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.va_inactive"
},
{
"name": "va_xa",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.va_xa"
},
{
"name": "i_ia_hirudin",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.i_ia_hirudin"
},
{
"name": "i_ia_atiii",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.i_ia_atiii"
},
{
"name": "apc_inactive",
"maps_to": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.apc_inactive"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Willems1991 Simulating Thrombin Generation Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_state"
],
"from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_summary"
],
"from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model_species_labels"
],
"from": "systemsbiology_sbml_willems1991_simulating_thrombin_generation_model1807240002_model.species_labels"
}
],
"package": "willems1991-simulating-thrombin-generation",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Mathematical model of blood coagulation to simulate factor IIa, Va and Xa concentration profiles. Publication also illustrates the effect of hirudin on factor IIa, Va and Xa generation.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagewillems1991-simulating-thrombin-generation
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother