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This a model from the article: A theoretical model of type I collagen proteolysis by matrix metalloproteinase(MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor ofmetalloproteinase 2. It can be used to explore systemsbiology karagiannis2004 collageniproteolysis model0911270007 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_t2",
"label": "Initial Model State T2",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_model_state_t2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `T2`."
},
{
"name": "initial_mt1t",
"label": "Initial Mt1t",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1t",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1t`."
},
{
"name": "initial_mt1cat",
"label": "Initial Mt1cat",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1cat",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1cat`."
},
{
"name": "initial_mt1_t2_star",
"label": "Initial MT1 T2 Star",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_star",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_star`."
},
{
"name": "initial_mt1_t2_m2_p_mt1",
"label": "Initial MT1 T2 M2 P MT1",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_m2_p_mt1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_M2p_MT1`."
},
{
"name": "initial_mt1_t2_m2_p",
"label": "Initial MT1 T2 M2 P",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.initial_mt1_t2_m2_p",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MT1_T2_M2p`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.species_labels"
},
{
"name": "model_state_t2",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.model_state_t2"
},
{
"name": "mt1t",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1t"
},
{
"name": "mt1cat",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1cat"
},
{
"name": "mt1_t2_star",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_star"
},
{
"name": "mt1_t2_m2_p_mt1",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_m2_p_mt1"
},
{
"name": "mt1_t2_m2_p",
"maps_to": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.mt1_t2_m2_p"
}
]
},
"tags": [
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Karagiannis2004 Collageniproteolysis Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_state"
],
"from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_summary"
],
"from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model_species_labels"
],
"from": "systemsbiology_sbml_karagiannis2004_collageniproteolysis_model0911270007_model.species_labels"
}
],
"package": "karagiannis2004-collageniproteolysis",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This a model from the article: A theoretical model of type I collagen proteolysis by matrix metalloproteinase(MMP) 2 and membrane type 1 MMP in the presence of tissue inhibitor ofmetalloproteinase 2. It can be used to explore systemsbiology karagiannis2004 collageniproteolysis model0911270007 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagekaragiannis2004-collageniproteolysis
Created2026-05-17
Updated2026-06-13
pharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother