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Mathematical modeling representing Tcell actiavtion regualtion by TCR, IL2 and other players. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cd4_cd8_binding_state",
"label": "Initial CD4 CD8 Binding State",
"units": "native source value",
"default": 40000,
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_cd4_cd8_binding_state",
"description": "Initial CD4 CD8 Binding State. Sets the initial value of bundled SBML species `CD4_8`."
},
{
"name": "initial_cd28_cd80_costimulation_complex",
"label": "Initial Cd28 Cd80 Costimulation Complex",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_cd28_cd80_costimulation_complex",
"description": "Initial Cd28 Cd80 Costimulation Complex. Sets the initial value of bundled SBML species `CD28_CD80`."
},
{
"name": "initial_tl_0",
"label": "Initial Tl 0",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_tl_0",
"description": "Initial Tl 0. Sets the initial value of bundled SBML species `TL_0`."
},
{
"name": "initial_unresolved_immune_observable_1",
"label": "Initial Unresolved Immune Observable 1",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_unresolved_immune_observable_1",
"description": "Initial Unresolved Immune Observable 1. Sets the initial value of bundled SBML species `T_0`."
},
{
"name": "initial_unresolved_immune_observable_2",
"label": "Initial Unresolved Immune Observable 2",
"units": "native source value",
"default": 1,
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.initial_unresolved_immune_observable_2",
"description": "Initial Unresolved Immune Observable 2. Sets the initial value of bundled SBML species `T_i`."
}
],
"outputs": [
{
"name": "cd4_cd8_binding_state",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.cd4_cd8_binding_state"
},
{
"name": "cd28_cd80_costimulation_complex",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.cd28_cd80_costimulation_complex"
},
{
"name": "tl_0",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.tl_0"
},
{
"name": "unresolved_immune_observable_1",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.unresolved_immune_observable_1"
},
{
"name": "unresolved_immune_observable_2",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.unresolved_immune_observable_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.species_labels"
}
]
},
"title": "Bidot2008 - Mathematical modelling of T cell activation kinetics Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_state"
],
"from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.state"
},
{
"to": [
"visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_summary"
],
"from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model_species_labels"
],
"from": "immunology_sbml_bidot2008_mathematical_modelling_of_t_cell_activ_model1910290003_model.species_labels"
}
],
"package": "bidot2008-mathematical-modelling-of-t-cell-activation-kinetics",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "Mathematical modeling representing Tcell actiavtion regualtion by TCR, IL2 and other players. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagebidot2008-mathematical-modelling-of-t-cell-activation-kinetics
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother